As it turns out one of the marginal items that gets trimmed in a down economy is conference jaunts [Q: who would have guessed? A: everybody]. PyCon 2010 needs talks, so if you have something interesting to say to a few hundred people this is your chance. I didn't volunteer for the program committee this year so I don't know the exact numbers but the acceptance rate is going to be much higher than the 50% for past years.
This is a great opportunity to practice your chops; I got my start when PyCon was 300 people and talks had a 90% acceptance rate. The last few years PyCon has had 1000+ people and even the smallest talk room gets 200 people. If you have anything interesting to say, this is your chance to say it.
NB, hopefully PyCon won't have to do what other conferences routinely do and say "we've extended the deadline, but this time we mean it!" For fuck's sake the conference is in Atlanta in February - I'll be happily golfing during the time I'm not speaking.
NB, by "golfing" I also mean "going to the shooting range" and "bowling" as weather dictates.
ENB: Anna Ravenscroft has a tidy short list of bogus reasons why you can't give a talk. The title is pointed at women but the excuses are universal.